9/5/2023 0 Comments Human clock![]() ![]() The stratum corneum is located at the outermost part of the body and thereby functions as the primary permeability barrier, preventing water loss from the skin surface 2. The epidermis is subdivided into several layers, including the stratum corneum, stratum granulosum, stratum spinosum, and stratum basale. It is a highly organized multilayered epithelium, divided into two compartments: the epidermis and dermis. The skin is the soft, outer covering tissue and plays a key role in protecting the body against hazardous environmental threats, such as pathogens, external chemical insults, heat, and water loss. The skin contains about 30% of total body water and serves a waterproofing function for the body 1. Water makes up about 60% of human body weight and plays an important role in maintaining tissue homeostasis in all biological physiologies. In conclusion, agerarin is a bioactive compound in AHE responsible for CLOCK-mediated AQP3 expression in keratinocytes. Agerarin (6,7-dimethoxy-2,2-dimethyl-2 H-chromene) was identified as the bioactive compound responsible for the up-regulation of AQP3 expression by enhancing the expression of the transcription factor circadian locomotor output cycles kaput ( CLOCK). Furthermore, AHE ameliorated suppression of AQP3 expression caused by ultraviolet B (UVB) irradiation. Here, we show that AHE increased AQP3 gene expression at the transcriptional level through the p38 MAPK pathway in HaCaT cells. houstonianum ethanolnolic extract (AHE) on the expression of aquaporin-3 (AQP3), an integral membrane protein for water and glycerol transport in keratinocytes, and to identify the structure of the A. ![]() This study was conducted to investigate the effect of A. houstonianum and its mode of action in skin wound healing has not been investigated. The juice of Ageratum houstonianum is used in folk medicine as an external wound healing aid for skin injuries. ![]()
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